December 2002 Meeting
The three hundred and thirty ninth meeting of the Section will be held on Wednesday, December 4 at 8:00 pm at Lycoming College in Williamsport, PA. The guest speaker, Dr. Michele Jetter from Johnson Pharmaceutical Research Institute, will present a talk entitled "Drug Discovery: Bradykinin (B2) Antagonists as Potential Analgesic Agents".Dinner will begin at 6 p.m. in the Miller Room of the Wilkes University Student Union (2nd Floor). Dinner will be a buffet at $11.00 cash or check. Please RSVP by Monday, December 2, to Mary Lou Gillespie 570-408-4750 or by e-mail to mencer@wilkes.edu.
The meeting will be at 8:00 p.m. in Room 207 of Breiseth Hall.
Directions: From I-81, Exit Route 309 North at Exit 3, Plains/Wilkes-Barre (River Street Exit). Make a left at the light at the end of the exit ramp, and follow River Street to Northampton St. (Wilkes University is on the left side of River St). The Student Union Building is one long block past Northampton St. on South St. The Breiseth Building is on Franklin St. mid-block between Northampton and South Sts. Detailed directions, maps can be found at www.wilkes.edu/pages/273.asp.
Drug Discovery: Bradykinin (B2) Antagonists as Potential Analgesic Agents
Bradykinin is an endogenous nonapeptide that is thought to play an important role in a variety of inflammatory diseases and pain. In mammals, the biological effects of kinins are mediated through two distinct bradykinin receptor subtypes, B1 and B2. Bradykinin B2 receptors are largely distributed in peripheral and central tissues and are present in neurons, endothelial cells, epithelial cells and fibroblasts. Because of the important role that kinins are believed to play in a variety of inflammatory diseases and pain, it is expected that bradykinin receptor antagonists may be useful in the treatment and prevention of various mammalian disease states, for example pain, inflammatory joint disease, inflammatory bowel disease, allergy and asthma.We have designed and synthesized several series of novel pyrrole alkylamide analogs that are potent antagonists at the B2 receptor. This presentation will highlight the synthesis and biological profile of these compounds. Through this example, the process of Drug Discovery at Johnson & Johnson Pharmaceutical Research and Development will be illustrated.
Michele Jetter received her PhD in 1989 from Lehigh University under Dr. Ned Heindel. From there, she did a 3 year post-doctoral appointment at Dupont Central Research in Wilmington, DE. There she worked with Dr. George Trainor on the design, synthesis and characterization of unnatural bases for incorporation into triplex DNA. In 1992, Michele joined the R.W. Johnson Pharmaceutical Research Institute in Spring House, PA. While at PRI she has been involved in the design and synthesis of novel therapeutics mainly in the area of analgesics. Presently Michele is a Senior Scientist at Johnson & Johnson Pharmaceutical Research and Development on the Analgesics team where her main focus is working on the discovery of new targets for pain management.
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