Susquehanna Valley Section

September 2004 Meeting

The three hundred and fifty first meeting of the Section will be held on Wednesday, September 8, 2004 at Bucknell University, Lewisburg, PA. The guest speaker, Dr. Jennifer L. Rutherford, will present a talk entitled "Application of New Technologies in Process Research and Development."

Reception: 5:00 p.m. in room 240 of the Langone Center
Dinner: 6:00 p.m. in room 241 of the Langone Center
Lecture 7:30 p.m. in room 116 of the Rooke Chemistry building

Dinner will be buffet style with one or more meat dishes as well as variety of sides such as mashed potatoes, salad, or a pasta dish. A choice of desserts will also be served. The cost will be $11 per person. Please RSVP to Suellen Haddon at (570) 577-3258 or haddon@bucknell.edu by Friday, September 3, 2004.

Directions:

From East or West of of Lewisburg:

1. Route 80 to Exit 210A
2. Route 15 South
3. At 9th traffic light, turn left (Look for the Bucknell Athletic Stadium.)

South of Lewisburg:

1. Routes 11&15 North
2. When Routes 11 & 15 split, stay on Route 15 (Tedd's Landing is on your right; KMart on your left)
3. Approx. 7 miles after Selinsgrove / Shamokin Dam, you'll come to a stop light. Bucknell is on your right. (Look for the Bucknell Athletic Stadium on right.)

North of Lewisburg:

1. Take route 15 south.
2. Once past route 80, turn left at the 9th traffic light (Look for the Bucknell Athletic Stadium on the left.)

Once on campus: Follow the campus map to the visitor parking designated with a P (white on blue back-ground).
More parking information.
A parking map of Bucknell.

Application of New Technologies in Process Research and Development
Process chemists in Chemical Research and Development (CRD) at Pfizer develop the scalable chemical routes for pharmaceutical drug candidates. In addition to the usual challenges facing a synthetic organic chemist, process chemists must also consider the robustness, safety and cost as the process is scaled from the lab bench to a few kilograms and then on to the manufacture of a commercial product. To effectively develop a robust process, a detailed understanding of the chemistry from a combination of physical organic and engineering perspectives is critical. Automated technology tools that can run reactions in parallel, monitor reactions in situ, and offer better temperature and mixing control are highly desirable to efficiently develop a better process. In this presentation, case studies will illustrate our implementation of automated technologies for process chemistry.

Dr. Rutherford received her joint BS/MS degree in chemistry from Bucknell University in 1995. As a freshman, she worked in the laboratory of Professor Harold W. Heine and then conducted her BS/MS thesis work with Professors Gretchen M. Rehberg and Brian W. Williams on a collaborative organic and physical chemistry project. She received her Ph.D. in chemistry from Cornell University in 2000. Her thesis work, under the supervision of Professor David B. Collum, included structural, mechanistic and computational studies of organolithium species. Following her Ph.D. studies, she was a National Institutes of Health postdoctoral fellow in the laboratory of Professor Stephen L. Buchwald at the Massachusetts Institute of Technology. Her research in the Buchwald group focused on the palladium-catalyzed a-arylation of ketones and the application of this methodology to the synthesis of substituted indoles. In June 2002, Jennifer joined the Chemical Research and Development (CRD) department of Pfizer in Groton, Connecticut. Within CRD, she is in the Technology/Automation Group under the direction of Dr. Joel M. Hawkins. The main goals of this group are to develop and apply new technologies to process chemistry and to utilize physical organic principles to understand, develop and improve the chemical processes in Pfizer's portfolio.